Perhaps the most important practical value of results of work of the Nobel prize in medicine associated with the development of new methods to combat inflammation, which in turn will help slow down the aging of people, told RIA Novosti leading researcher of the research Institute of physicochemical biology behalf Belozersky MSU Maxim Skulachev.
The Nobel prize in medicine for 2019 was awarded to William Kelin, Gregg a Semenets (both USA) and Peter Ratcliffe (great Britain) for the discovery of how living cells react to changes in the level of oxygen in the body, including oxygen starvation (hypoxia), announced Monday in Stockholm the Nobel Committee at Karolinska medical Institute. Of Semenets, in particular, discovered in the cells of a molecule HIF-1A involved in the regulation of cellular response to fluctuations in oxygen levels.
“It’s great that the Nobel Committee drew attention to this area of biochemistry. We are talking about the fact that the opening of the current laureates are important for the treatment of cancer, heart attacks, ischemic strokes and many other diseases. But, in my opinion, the most important is the ability to fight inflammation and, moreover, with aging. Because inflammation is a part of aging. Different and chronic inflammation are much more people than cancer, heart attacks and strokes,” said Skulachev.
He explained that in the development of inflammatory processes involved the so-called active forms of oxygen (free radicals). “And this is directly related to HIF-1A,” – said the scientist. “HIF-1A – he, figuratively speaking, a spider in the web and pulling different strings, adjusting in the cell, including the activity and number of mitochondria – the cellular “power stations,” said Skulachev. According to him, the mitochondria, through feedback, through the production of reactive oxygen species control the functioning of molecules of HIF-1A.
“And because the active forms of oxygen, and it is proven to be one of the most significant aging factors, it ties the work of Nobel laureates with the study of mechanisms of aging, and possibly with the development of approaches for anti-aging,” – said the expert.