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Scientists from the Marine biological laboratory, tel Aviv University and the University of Colorado in Denver for the first time found the animal’s ability to edit their own genes outside the cell nucleus. This feature was found in the squid species Doryteuthis pealeii. The work of researchers published in the journal Nucleic Acid Research.
In humans, dysfunction of axons — thin “filaments” conducting the signal between neurons — is associated with many neurological disorders. Understanding how to alter the genetic sequence in these structures will help to develop new therapies based on gene editing.
In 2015, researchers found that squids change their instructions for the transfer RNA to an extraordinary degree of magnitude more than humans, allowing them to accurately set the range of proteins that are synthesized in the nervous system. But then the researchers thought that RNA editing occurs in the nucleus, then modified mRNA is exported into the cell. But now the same team of scientists showed that the squid can modify RNA at the cell periphery.
In theory, this means that they can modify the function of its proteins to meet the needs of the cell. This gives them great freedom for genetic adaptation when the need arises. In the new work, the researchers also showed that mRNA edited in AXONE nerve cells much faster than in the nucleus.
In addition, the researchers found that octopuses and cuttlefish are also heavily rely on the editing of mRNAs for the diversification of proteins that are synthesized in the nervous system. Together with squid these animals are known for amazingly complex behaviour compared with other invertebrates.
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