Scientists from China have figured out the mechanism of drug action of ramdevpir the coronavirus SARS-CoV-2. The results of a study published in the journal Science.
The study showed that the active substance inhibits RNA polymerase (replicase), which plays a key role in the reproduction of the pathogen coronavirus.
RNA virus SARS-CoV-2 infects cells through the mucosa and multiplies rapidly in them. For this you need fast copying of RNA. In this process involved the transcription complex, consisting of multiple non-structural proteins. The key element here — replicase serving as a target to develop and test drugs, including ramdevpir.
For the study, researchers used the method cryoelectron microscopy. With its help, managed to figure out how ramdevpir inhibits the activity of the replication enzyme SARS-CoV-2. This was a detailed structure of RNA polymerase in the free and bound form. It turned out that replicase virus doesn’t change its structure when copying RNA. According to scientists, this explains the high ability of the virus to infect the body.
Ramdevpir suppresses viral replication, reacts with his genome and inhibiting the action of the replication enzyme. This mechanism is effective for different groups of viruses.
Scientists think it is possible to develop, on the basis of this mechanism of antiviral drugs with broad spectrum of action.
Pandemic coronavirus has spread to almost the whole world. The who reports that more than 3.3 million are infected, of which approximately 238 thousand died and over a million have been cured.
Most infected and victims recorded in USA, Spain and Italy. China, in turn, managed to defeat the epidemic.
Russia takes the seventh place for the number infected. The country COVID-19 diagnosed 134 687 people (per day 10 663 new cases), of which gained more than 16 thousand people. Victims of the disease become 1280 patients.
Recent data on the situation of COVID-19 in Russia and the world presented on the portal stopmanager.of the Russian Federation.